I swear by this formation:
DR DC DC DL
Usually, my left sided CM is the creative one (free role, gets forward, attacking mentality and tries through balls) where the right sided CM is the "ball winning midfielder" with his mentality set to "support". The DM is there to sweep anything up, that my ball winner misses and both of those pass short, so the attacking players can spend more time in possession.
Both wingers get to the byline, and my full backs cross from deep (for some reason on FM10 a number of them end up over the keeper and into the far corner...strange but I'll take a goal thanks!).
The system is made for your lone striker to be a goal machine. I often get called a one-man team in network games with mates because the striker has a superb scoring record, whereas the next in the scoring charts are way behind him (usually a winger or the attacking CM). Eg. Just finished a season with Sporting Lisbon where Liedson got 36 goals in 51 games.